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- Creator:
- Blackwell, Hope
- Description:
- In my thesis exhibition, clandestine: conversations with a shadow, I render elements of my psyche to act as a window for the outside world, exploring the psychological concept of the shadow self. The concept of the shadow self, is a psychological archetype suggested in research conducted by psychologist Carl. The shadow self is understood to be the repressed unconscious of an individual that can manifest in feelings or thoughts that contradicts the character of an individual. The research of Jung was the foundation for this exhibition alongside my personal experience with the loss of my father. This exhibition consists of projected still images and videos that attempt to bring the shadow self and the exploration of loss out of the subconscious and into the physical world. I use lens-based media to record my body as the primary subject for this work. The gallery installation is meant to become the physical representation of my mind, where the shadow lives, creating an environment where viewers can encounter something that normally is not seen.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Art and Art History
- Creator:
- Aguiar, Stephanie
- Description:
- Chronic myeloid leukemia (CML) is a disease that affects the normal growth of myeloid cells, which are blood cells that protect the body against foreign invaders in the blood and bone marrow. In humans, 95% of CML cases are caused by a chromosomal translocation that inappropriately links the breakpoint cluster region (BCR) to Abelson murine leukemia viral oncogene-1 (ABL1), forming a mutant oncogene called BCR-ABL1 . A protein that physically interacts with BCR-ABL1 is growth receptor bound protein-2 (GRB2), an intracellular adaptor protein involved in cell growth and differentiation. Specifically, BCR-ABL1 binds to a region of GRB2 known as the SRC homology-2 (SH2) domain. This interaction transforms hematopoietic stem and progenitor cells, initiating leukemic transformation. The current frontline therapy to treat CML is a tyrosine kinase inhibitor, imatinib. Some patients have developed a resistance to imatinib, and thus the demand for additional anticancer drugs are needed. To prevent growth of CML cells, Dr. Arpin and her students of the CSU Chemistry and Biochemistry department created two novel SH2 antagonists (NHD2-15 and NHD2-114) and we tested their ability to prevent cell proliferation in the human BCR-ABL1 + K562 myelogenous leukemia cell line. The most significant growth reduction was observed 72 hours after the addition of 30 μM of NHD2 - 15. Furthermore, adding drugs combinatorially (60 μM NHD2-15, 30 μM NHD2-114, and 1 μM imatinib) to K562 cells showed over 2-fold growth reduction than with imatinib alone. To assess if these compounds are toxic to living organisms, we added the two compounds individually to the water of healthy adult zebrafish, and found that NHD2-15 was non-toxic. After using an enzyme-linked immunosorbent assay (ELISA) we also found that these two novel drugs exhibited prominent binding affinities to GRB2; NHD2-15 with K d = 119 ± 2 μM, and NHD2 - 114 with K d = 440 ± 7 μM (Lewis et al., in revision, 2019). Western blots were performed to determine the pathway these novel antagonists in fluence, and to ultimately indicate if these drugs stop cancerous cell proliferation via the Janus kinase signal transducer and activators of transcription (JAK/STAT) pathway, as well as the mitogen-activated protein kinase and phosphoinositide 3-kinase (M APK/PI3K) pathway. Results of western blotting indicated that the combinatorial treatments of both novel drugs reduces expression of proteins involved in both the JAK/STAT and MAPK/PI3K pathways, suggesting these compounds inhibit different target proteins within BCR-ABL+ cells to decrease leukemic cell proliferation. This research should provide an additional alternative treatment for patients who develop imatinib resistance.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Biological Sciences
- Creator:
- Maxey, Tamara
- Resource Type:
- Thesis
- Campus Tesim:
- Chico
- Department:
- Anthropology
- Creator:
- Smart, Jay W.
- Resource Type:
- Thesis
- Campus Tesim:
- Chico
- Department:
- Geosciences
5. A soft word
- Creator:
- Blank, Malinda
- Resource Type:
- Thesis
- Campus Tesim:
- Chico
- Department:
- Art
- Creator:
- Tjarks, Heyo
- Resource Type:
- Thesis
- Campus Tesim:
- Chico
- Department:
- Biological Sciences
- Creator:
- Morgan, Jason P. T.
- Description:
- Summer camps in the US gross more than $18 billion in revenue while providing over 14,000 individual programs. Summer camp counselors, like other outdoor workers, are at risk of occupational solar exposure. Occupational solar exposure increases an individual’s lifetime accumulation of solar radiation, leading to skin damage and higher rates of skin cancer. This study fills a gap in the research about the sun protection behaviors of summer camp counselors and their attitude towards provision of sun protection for themselves and the campers in their care. Counselors’ usage of sun protection measures were found to be inadequate. Most counselors were either unprotected or under-protected from occupational solar exposure. Female counselors were significantly more likely to use sun protection measures and reported a higher desire to protect themselves and their campers from solar exposure. Counselors who used sun protection measures for themselves were significantly more likely to feel responsibility for protecting their campers from solar exposure. These findings suggest that summer camps are not adequately protecting their staff from occupational solar exposure. This leads to the conclusion that the Occupational Safety and Health Administration is failing to hold summer camps accountable to protect this group of employees from a known workplace hazard. The findings have implications for hiring, training, and risk management practices at summer camps.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Recreation, Hospitality, and Parks Management
- Creator:
- Gradone, Dayne Anthony
- Description:
- Making sense of health practices requires attention to the lives and experiences of the individuals and collectivities involved in them, along with a basic understanding of the historical, sociocultural, political economic, and ecological contexts that structure and inform those practices and individuals. This applies to Iten, Kenya, a small town located in the western highlands of Kenya. Iten's plethora of both conventional health facilities and traditional herbalists, known as chepkerichinik, make it an intriguing place to study the interactions of traditional and western medicine. Based on four months of ethnographic fieldwork in Iten Kenya, this study explores the role chepkerichinik play as community healthcare providers, entrepreneurs, culture bearers, and the physical embodiments of Kalenjin tradition. Semi-structured interviews with sixteen Kalenjin herbalists reveal that chepkerichinik provide at least forty-two medical services to community members, and routinely base their treatments on herbal remedies that have been maintained in their families for multiple generations. The study concludes that chepkerichinik remain important purveyors of community healthcare, and provide services that not only address the major disease burdens of the community, but also "fill the gaps" where biomedical services are perceived to be the most deficient. Through describing the role of Kalenjin herbalists, the cultural contexts of their remedies, and the reality of interpenetrating medical pluralism, this work demonstrates the need for close, granular analyses of medical systems in an effort to understand the durability and mutability of tradition in the face of profound cultural changes.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Anthropology
- Creator:
- Flett, James "Saylor"
- Description:
- Vocational preparation programs in institutions of higher education aim to develop skill sets that transfer to participants post graduate experiences. The literature suggest that outdoor education programs aim to increase technical, interpersonal, and meta skills in its participants; however, few studies have included long-term, follow up assessments of college graduates from outdoor recreation experiential education programs to see if the learning outcomes are transferrable and long lasting. This research provides an analysis of the effectiveness of experiential education in higher education through looking at alumni from the Outdoor Recreation Leadership program at Feather River College. A mixed methods research approach, utilizing surveys and follow up interviews (N=73), is used to assess the impact of experiential education on program participants. The results of this study indicate that student alumni believe their experience at Feather River College positively prepared them for postsecondary education, employability and job decidedness, and transferrable skill development in their professional and personal postgraduate lives. It is evident from the data and emergent student narratives that the experiential education model used by the Outdoor Recreation Leadership program at Feather River College effectively serves ORL alumni in their post-graduation experiences. The knowledge gained from this study reveals that educators in institutions of higher education should carefully develop and intentionally integrate more experiential education practices into their programs and curriculum.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Recreation, Hospitality, and Parks Management
10. The effects of blood glucose concentration on decision making in the context of outdoor education
- Creator:
- Faris, Ellsworth, IV
- Description:
- It has been hypothesized that some accidents in the backcountry are due to individuals being hypoglycemic (low blood glucose concentration). Glucose is the brain’s main energy source. Without proper blood glucose concentrations, the brain’s functionality decreases. When this happens the ability to make decisions may be impaired. In outdoor education, instructors, students, and staff are actively involved in decision making which includes choices affecting the safety of themselves as well as others. The purpose of the study was to examine if blood glucose concentration affects the ability to make decisions in the context of outdoor education. The study was a blind randomized cross-over design in which half the subjects consumed a carbohydrate replacement beverage while the other half consumed artificially flavored water as a placebo. Six subjects participated in the study and hiked 10.2 miles with 25% of their body weight to simulate the activity of backpacking. During predetermined time intervals, the subjects would have their blood glucose concentration measured and performed a basic decision making test. The results of this study showed that drinking a carbohydrate replacement drink had a significant effect on blood glucose concentrations; however, it did not show that blood glucose concentration had an effect on decision making. Current literature supports that blood glucose concentration does have an effect on decision-making. Understanding the physiological impacts of blood glucose concentration in relation to decision making can further improve risk management practices of outdoor education programs.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Interdisciplinary Studies
- Creator:
- Nielsen, Ryan
- Description:
- The area of study for this project is a microRNA called miR-375 which is overexpressed in people with type 2 diabetes (T2D) and has been linked to decreased insulin secretion and beta cell proliferation. Investigation into the transcription factor inducible cAMP early repressor (ICER) as an intermediate regulator of miR-375 was proposed because both were found to be regulated by cAMP pathway. To investigate ICER’s binding affinity to the miR-375 promoter, a luciferase reporter assay was conducted. HEK-293T cells that were transfected with a luciferase reporter plasmid containing a cAMP recognition element (CRE) and a plasmid driving the overexpression of ICER had a 75% decrease when compared to our control (p < 0.05). Additionally, ICER’s expression was measured in human embryonic kidney cells (HEK-293T) when co-transfected with a plasmid containing ICER and a small interfering RNA (siRNA) using quantitative real time PCR (qPCR) and Western blot. A luciferase reporter assay showed a 13.1-fold increase from the miR-375 luciferase reporter plasmid containing the AP-1 promoter (p < 0.05). INS-1 cells that were transfected with a luciferase reporter plasmid the miR-375 promoter and a plasmid driving the overexpression of ICER had no significant fold change when compared to the control (p > 0.05). The goal of this project was to test the potential binding and regulation of the miR-375 promoter by ICER. The findings that I made indicate that there is potential binding and further investigation into this area could lead to a better understanding of the cAMP dependent regulation mechanism of miR-375.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Biological Sciences
- Creator:
- Howell, Matthew
- Description:
- Proliferation of nuclear weapons is currently one of the most critical issues facing international relations. The region where this is currently of greatest concern is the Middle East. The Islamic Republic of Iran is an emerging regional power in the Middle East and has had an advanced nuclear weapons program. Iran's nuclear threat was supposed to be resolved with the Joint Comprehensive Plan of Action (JCPOA), however the two main signatories, the US and Iran, have pulled out. Understanding the behavior of Iran and the situation with Iran's nuclear program is therefore of critical importance, which this thesis addresses through a review of contemporary international relations theory. Iran's behavior is clearly a pragmatic and survival based approach in reaction to Iran's environment, best explained by the offensive realism theory of John Mearsheimer in The Tragedy of Great Power Politics. This is proven by analyzing and comparing the behavior of Iran with the behavior of other states in a similar situation to Iran, within the framework of offensive realism. A case study of nuclear-armed states and other states in the region that have attempted to obtain nuclear weapons is used to review the variables that indicate which direction a rational state will take in the context of nuclear proliferation. It is determined that it is logical for Iran to pursue a nuclear deterrent, and this outcome should be expected and prepared for.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Political Science and Criminal Justice
13. Reasons to worry
- Creator:
- Allen, Ian T.
- Description:
- Reasons to Worry is a collection of short stories and flash fiction focused on the traditions of literary fabulism and speculative fiction. Their genres span across cyberpunk, gothic, folklore, science fiction, horror, magical realism, and cosmicism. Each narrative explores different aspects of anxiety, self-identity, and personal metamorphosis, often interweaving humor, satire, and hyperbole to emphasize these themes and to create undercurrents of meaning. Reasons to Worry also seeks to blur the lines between what is considered the real and the fantastic, posing the question of “what if?” and seeks to eventually supplant this speculation with the revelation of “what is.” The critical introduction of this project provides a deeper examination of its incorporated craft elements such as the strategic use of genre, subtlety, and form. It expands on these with examples supplemented by the works of Charles Baxter, Rob Davidson, Tara L. Masih, Herman Melville, Maria Romasco Moore, Annie Neugebauer, Virgilio Piñera, and Neal Stephenson. Additionally, it touches on a few of its methods of inspiration, revision, and the evolution of its overall style into its current iteration.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- English
- Creator:
- Cahill, Daniel
- Description:
- Our understanding of the contemporary museum is changing. Gone are the days of looking at the museum as a stuffy institution with glass cases, stanchions, and “don’t touch” signs. Today’s museums have become dynamic, interactive, and family-oriented centers of exploration and learning. Reflecting on the social change that surrounds them, museums have evolved alongside technology. Moore’s Law is a prediction and forecast that technology only moves forward, and doubles every year. Whether it is the number of circuit boards or memory, computers and technology are always pushing forward. This push is impacting museums across the world, calling for the integration of digital technologies in museum programming to offer new and exciting exhibitions, access to collections, and program incentives to their patrons. With these exciting changes to museums, there is a growing disparity between the application of technology in museums and what they provide as pedagogical tools for museum work and training. Many museums integrate new technologies, such as 3D scanning and Virtual Reality (VR) into exhibition and collection management work, digitally knocking down the four walls of the museum exhibit and bringing artifacts into the living room. While these technologies may stimulate museum patrons and speak directly to connecting museums to our current digital age, museums have failed to employ these technologies as pedagogical tools for museum training and project development. This thesis presents the use of 3D scanning coupled with Virtual Reality (VR) as a pedagogical tool for training future museum professionals - university museum studies students. Through the creation of a 3D previsualization of the exhibition space at the Valene L. Smith Museum of Anthropology, at California State University, Chico, university students will have the capacity to intuitively and interactively develop new museum exhibition designs and layouts using virtual reality. The thesis articulates the development and applicability of using this previsualization technology to enhance knowledge of 3D scanning and VR and provide immersive learning experiences for university museum studies students. The thesis project demonstrates the utility in current digital technology as pedagogical tools to boost museum studies educational programs, training, and the future of museum development.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- Interdisciplinary Studies
- Creator:
- Jena, Sourav
- Description:
- Solar energy is amongst the fastest growing renewable energy source in the 21st century. The research and development of panel efficiency over the course of the last 40 years has proliferated the scale of photovoltaic (PV) systems to reach grid parity. The objective of this project is to address the energy crisis of a hospital that currently uses diesel generators as the sole source of electricity. To ameliorate the current operating condition, a 25 kW PV power plant is to be constructed in Ozu Abam, Nigeria. A comprehensive study on the fundamentals of PV systems is presented. This is followed by a design phase involving the investigation of PV system components that are available in the market. The implications of component selection have been analyzed and compared to present a viable solution.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- Computer Science
- Creator:
- Tran, Tiffany L.
- Description:
- No abstract.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- Social Work
- Creator:
- Smith, Jennifer L.
- Description:
- Touch the Stars/Touch the Earth is a collection of four short stories that explore themes of grief, death, loss and agency through the medium of fiction, specifically using the genres of fabulist and science fiction. Each story has a central theme of loss and a regaining of agency. Each story uses genre to get at issues that are utterly mundane: the loss of a loved one, feeling stagnant, the process of being depressed and possibly suicidal, an unwanted pregnancy. Prefacing these stories is a discussion dwelling on the influences, theories, and popular culture that have helped shape the creative work, in particular the writing of Ursula K. Le Guin, English folk ballad Tam Lin, and numerous discussions that have taken place both online and in the real world regarding representation and how diversity is echoed or not echoed in popular fiction.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- English
- Creator:
- Martinez, Zeth M.
- Description:
- The Cost of Freedom and Other Stories is a collection of interconnected fictional short stories that turn the internal conflict into a tangible obstacle the characters must overcome. By exploring themes of escapism, obsession, and toxic patterns, The Cost of Freedom and Other Stories takes a hybrid approach to the genres of Cyberpunk and Fabulist Fiction. This hybridity allows the fabulist elements to take on a more active role in the plot of the story. The critical introduction discusses the craft elements of defamiliarization and characterization as they explore the fabulist elements of the stories. The authors discussed in the critical introduction are Kôbô Abe, Charles Baxter, John Ajvide Lindqvist, Gloria Naylor, Marge Piercy, and Victor Shklovsky.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- English
- Creator:
- January, Morgan P.
- Description:
- The proposed curriculum in this project combines the practices of journalism education, news media literacy, and 11th grade U.S. history. The journalism lessons and activities included in this curriculum are aligned with the standards and expectations of the California Department of Education, the U.S. Department of Education, and the California Common Core Standards. This project identifies the intuitively symbiotic relationship between journalism and history education. It uses that relationship to enhance levels of student engagement, academic achievement, and two aspects of civic engagement: current events knowledge and a desire to engage in civil discourse. It consists of lessons and activities that are organized into three sections: journalism writing, journalism in U.S. history, and a project that combines history and journalism practices. Ideally, teachers would select lessons from each section, but they do not have to in order to be effective. Additionally, lessons from each section do not have to be implemented in a specific order. These lessons and activities are designed to promote student choice, critical thinking, collaboration, and real-world application of the skills and knowledge acquired.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- Social Work
- Creator:
- Arvikar, Anurag Yeshwant
- Description:
- The scarcity of electricity and the limited number of conventional energy resources are affecting the overall development of Nigeria. Renewable energy resources can meet the ever-increasing demand for electricity in urban and remote places in Nigeria. Solar energy is one of the excellent options for power generation. Solar energy is abundantly available and cost-efficient. The main aim of the project is to generate 5 kW of solar energy. The generated energy will power the lighting and cooling requirements for a clinic in Ozu Abam, Nigeria. The project provides a critical aspect of solar power plant design. The project includes a literature review and a survey of the existing technologies and the effects of external factors such as shading, soiling on the PV panels. Further, it explains the clinic load estimation, PV panel tilt angle calculations, effective insolation calculations, and the solar panel type required for the design. The selection of a fixed tilt angle of 5.33° for an entire year and the effective insolation of 684.02 W/m2 proved to accomplish the requirement of 5-kW power generation for the clinic usage.
- Resource Type:
- Project
- Campus Tesim:
- Chico
- Department:
- Computer Science