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- Creator:
- Center for Healthy Communities
- Description:
- The California State University Basic Needs Training & Resource Center (BNTRC) was an SB 85 funded Innovation project, implemented by CSU Chico’s Center for Healthy Communities (CHC). The ultimate goal of the BNTRC is to elevate and align basic needs programing efforts across the California State University system. The primary outcomes for this SB-85-funded Innovation award BNTRC project include: 1) identifying the basic needs topics that campuses have requested or need, 2) creating web-based intervention training modules for CSU campus staff and interns to address these gaps and needs, 3) pairing these BNTRC modules with available technical assistance support from CHC to ensure proper use and to answer questions, 4) assess the impact and use of these BNTRC resources using a pre-to post study design, 5) disseminating the BNTRC to the CSU campuses for long-term access state-wide.
- Resource Type:
- Presentation
- Campus Tesim:
- Chico
- Department:
- Nutrition and Food Science, Media Arts, Design, and Technology, and Mathematics and Statistics
- Creator:
- Center for Healthy Communities
- Description:
- Food insecurity among college students is problem that can impact student performance in the classroom and ultimately effect student success. The Center for Healthy Communities (CHC) developed the Basic Needs Student Success Survey (BNS3) and administered it to undergraduate students at California State University, Chico in April 2019. The Educational Opportunity Program (EOP) office assisted in the recruitment and provided computers for students to take the survey. Participants were given a $25 gift card for their participation. Initially, EOP students were identified as the target population for this survey because of their low-income and first-generation status which makes these students more likely eligible to qualify for CalFresh. The purpose of this cross-sectional pilot study was to create a tool that identifies student perception of the impact of receiving CalFresh assistance on their health, nutrition, cooking confidence, time management and academic performance. This report provides a top level descriptive analysis of each question in the survey. Researchers and campus staff are encouraged to review the information in this analysis to formulate research questions and hypotheses. These results can be found at: https://chicocalfresh.github.io/bns-website/index.html
- Resource Type:
- Presentation
- Campus Tesim:
- Chico
- Department:
- Nutrition and Food Science, Social Science, and Mathematics and Statistics
- Creator:
- Blackwell, Hope
- Description:
- In my thesis exhibition, clandestine: conversations with a shadow, I render elements of my psyche to act as a window for the outside world, exploring the psychological concept of the shadow self. The concept of the shadow self, is a psychological archetype suggested in research conducted by psychologist Carl. The shadow self is understood to be the repressed unconscious of an individual that can manifest in feelings or thoughts that contradicts the character of an individual. The research of Jung was the foundation for this exhibition alongside my personal experience with the loss of my father. This exhibition consists of projected still images and videos that attempt to bring the shadow self and the exploration of loss out of the subconscious and into the physical world. I use lens-based media to record my body as the primary subject for this work. The gallery installation is meant to become the physical representation of my mind, where the shadow lives, creating an environment where viewers can encounter something that normally is not seen.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Art and Art History
- Creator:
- Aguiar, Stephanie
- Description:
- Chronic myeloid leukemia (CML) is a disease that affects the normal growth of myeloid cells, which are blood cells that protect the body against foreign invaders in the blood and bone marrow. In humans, 95% of CML cases are caused by a chromosomal translocation that inappropriately links the breakpoint cluster region (BCR) to Abelson murine leukemia viral oncogene-1 (ABL1), forming a mutant oncogene called BCR-ABL1 . A protein that physically interacts with BCR-ABL1 is growth receptor bound protein-2 (GRB2), an intracellular adaptor protein involved in cell growth and differentiation. Specifically, BCR-ABL1 binds to a region of GRB2 known as the SRC homology-2 (SH2) domain. This interaction transforms hematopoietic stem and progenitor cells, initiating leukemic transformation. The current frontline therapy to treat CML is a tyrosine kinase inhibitor, imatinib. Some patients have developed a resistance to imatinib, and thus the demand for additional anticancer drugs are needed. To prevent growth of CML cells, Dr. Arpin and her students of the CSU Chemistry and Biochemistry department created two novel SH2 antagonists (NHD2-15 and NHD2-114) and we tested their ability to prevent cell proliferation in the human BCR-ABL1 + K562 myelogenous leukemia cell line. The most significant growth reduction was observed 72 hours after the addition of 30 μM of NHD2 - 15. Furthermore, adding drugs combinatorially (60 μM NHD2-15, 30 μM NHD2-114, and 1 μM imatinib) to K562 cells showed over 2-fold growth reduction than with imatinib alone. To assess if these compounds are toxic to living organisms, we added the two compounds individually to the water of healthy adult zebrafish, and found that NHD2-15 was non-toxic. After using an enzyme-linked immunosorbent assay (ELISA) we also found that these two novel drugs exhibited prominent binding affinities to GRB2; NHD2-15 with K d = 119 ± 2 μM, and NHD2 - 114 with K d = 440 ± 7 μM (Lewis et al., in revision, 2019). Western blots were performed to determine the pathway these novel antagonists in fluence, and to ultimately indicate if these drugs stop cancerous cell proliferation via the Janus kinase signal transducer and activators of transcription (JAK/STAT) pathway, as well as the mitogen-activated protein kinase and phosphoinositide 3-kinase (M APK/PI3K) pathway. Results of western blotting indicated that the combinatorial treatments of both novel drugs reduces expression of proteins involved in both the JAK/STAT and MAPK/PI3K pathways, suggesting these compounds inhibit different target proteins within BCR-ABL+ cells to decrease leukemic cell proliferation. This research should provide an additional alternative treatment for patients who develop imatinib resistance.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Chico
- Department:
- Biological Sciences