Worldwide, there are 65 million people that have epilepsy and approximately 200,000 additional individuals are diagnosed with epilepsy annually. There is no cure and currently available anticonvulsants, which are medications to treat seizures, are not . . .

This study involved Drosophila melanogaster, the common fruit fly, as the model organism to study the behavioral differences seen in flies overexpressing the human tau protein throughout their adult life span. The tau protein (MAPT – microtubule ass . . .

The Escherichia coli cAMP receptor protein (CRP) requires both DNA binding and RNA polymerase recruitment for its transcriptional activation function. The DNA recognition of CRP is performed by the F-helix (residues 180-185) and several F-helix resi . . .

Bacteria must be able to withstand a myriad of stresses from both their environment, and in the case of pathogens, from their host. Low molecular weight thiols serve as redox buffers to maintain a reducing environment in the cell and participate in va . . .

Discovered in 2004, tunneling nanotubes (TNTs) are actin-based, bridge-like structures that allow the intercellular transport of cellular components, electrical signals, and pathogens. Thus, TNTs have been implicated in viral propagation, neurodegener . . .

Tunneling nanotubes (TNTs) have been recently discovered as an essential form of cell-cell communication in multicellular organisms. Although TNTs appear to be an important cell-cell signaling pathway, its mechanism of formation and functions are st . . .

Bacterial second messenger, c-di-GMP, regulates important functions such as biofilm formation, motility, and virulence. C-di-GMP also has an immunostimulatory property, so can be used as a vaccine adjuvant. In this project, DgcZ (a diguanylate cycla . . .

Clearcut logging of numerous small stands of trees over the last fifteen years has provided suitable areas for the study of early secondary plant succession on the western slope of the central Sierra Nevada mountains. Familiarity with early succession . . .

Six species of Simulium larvae found in the Kings River near Piedra, Fresno County, California, are described. The black fly larvae and pupae were reared in the laboratory for taxonomic association of the immature instars, the pupae and the adults. . . .

Nitidulid beetles have been recognized as major pests of figs In California since 1900 (Simmons et al., 1931). Early workers were concerned primarily with Carpophllus hemlpterus (Linnaeus), the dried-fruit beetle, as the principal nitidulid pest ( . . .

The natural history of the Fresno kangaroo rat, Dipodomys nitratoides exilis, in the San Joaquin Valley's alkali sink habitat was first described by Culbertson (1946). His study included little information on the interspecific interactions with ot . . .

The California State Park system, hereafter referred to as CalDPR, has sought for five years to include Carmel Bay, California, in its park system as an underwater park. Carmel Bay is approximately 15 km (5 mi ) in area, located between Pescadero Poin . . .

An important aspect of any group of organisms from both ecologic and evolutionary points of view is the part played by that group in channeling the flow of energy within the community in which it lives. Foraminifera, marine protozoans with calcium car . . .

The primary purpose of this study was to-investigate the feeding habits of silversides (Family Atherinidae) in Elkhorn Slough, Monterey Bay, California, since little detailed work on the feeding habits of silversides from California has been pub . . .

The field of membrane investigation is over 80 years old. Yet that remarkably complex and diverse structure, the cell membrane, continues to elude precise definition of structure and function. Observers have found cell membranes to be involved . . .

The rate of growth of catfish farming in the United States during the past 16 years is. unequalled in the history of fish culture. Commercial production of channel catfish (Ictalurus punctatus) has increased from its beginnings in 1960 to an estim . . .

The presence or absence of intestinal parasites in a human population is one indication of the quality of life the people lead. Particularly, human intestinal helminths and protozoans have been used to indicate the sanitary standards of a populatio . . .

Shortly after the discovery of the role of bacteria as the etiological agents of human disease, the search for bacterial toxins began. Bacterial toxins were an important discovery, because they may enhance the pathogenicity of infection; the effect of . . .

Previous work on the North Kings deer herd has shown that the reproductive potential of the does was high; however, there was a 50 percent neonatal loss of fawns. The neonatal loss was hypothesized to be the result of a nutritional stress expe . . .

Ranch ponds are numerous in the foothills of the western Sierra Nevada. An article appearing in the California Cattleman (anon, 1975) estimated that there were more than 50,000 ponds of less than 0.0123 cubic hectometers (10 acre feet) in California. . . .