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- Creator:
- Hernández, Alejandro
- Description:
- Chalcones are aromatic ketones that form the central core for a variety of important biological compounds. Previous research in Dr. Calderón-Urrea’s laboratory showed the efficacy of eight chalcones (1, 16, 17, 18, 19, 22, 25, and 30) to kill Caenorhabditis elegans. The chalcones cause 100% mortality, not only in C. elegans but also the plant parasitic nematode Meloidogyne incognita, at concentrations of 10-4 M (Singh, 2013). Furthermore, chalcones 17, 25, and 30 effectively kill at even lower concentrations (10-5 M). However, the mechanism by which the chalcones kill the nematodes is not known. Previous work, also from Dr. Calderón-Urrea’s laboratory, identified a mutant in the C. elegans strain PD4251 that is resistance to Chalcone 17, and this new mutant strain was named strain RT-Ch17.1.2. Here we set out to identify the DNA sequence responsible for the mutant phenotype of strain RT-Ch17.1.2 using a combination of genetics, whole genome sequencing (WGS), and bioinformatics tools. I identified six single nucleotide polymorphisms (SNPs), corresponding to two genes; these two genes are therefore candidates involved in resistance of RT-Ch17.1.2 to chalcone 17. These two genes are the mitochondrial ribosomal protein large subunit (mrlp-15), and a 5'-to-3' DNA helicase (pif-1). Both of these genes play a role in the proper functioning of the mitochondria, which suggest that the chalcones may target essential elements of the mitochondria to cause lethality in the nematodes.
- Resource Type:
- Thesis
- Campus Tesim:
- Fresno
- Department:
- Biology
- Creator:
- Gómez, Mindy Danira
- Description:
- Research supports attractive food cues, such as olfactory cues, in our environment have a strong impact on eating behavior (Yeomans, 2006); however, research on olfactory cues has been mixed. Research demonstrates that brief olfactory exposures may increase responding for food; however, it also demonstrates that repeated exposures may decrease responding for food. It may be that olfactory cues can both increase and decrease responding for food, and habitation may be able to explain both phenomena as sensitization and habituation. However, most studies have focused on responding for food and measuring salivation, with consumption as a secondary measure. Larsen, Hermans, and Engels (2012) were the first to examine olfactory exposure lengths on food consumption, but results did not yield significant effects. The current study also examined the effects of olfactory exposure lengths on food consumption. A total of eight university students were exposed to three durations of a pizza smell (0 min, 10 min, and 15 min) and were then presented with pizza to consume. Additionally, each participant was exposed to a cookie smell to determine whether stimulus specificity would be observed. Results indicate that duration of olfactory cue exposure had no effect on food consumption or response rate as no differentiation was observed between conditions. Furthermore, stimulus specificity could not be determined due to lack of differentiation between conditions. Limitations of this study may have contributed to the results. Future research is warranted to address these limitations and further investigate the effects of environmental stimuli on food consumption.
- Resource Type:
- Thesis
- Campus Tesim:
- Fresno
- Department:
- Psychology
- Creator:
- Heckman, Vernon L
- Description:
- It is the purpose of this study to determine how many elementary school districts in California over 400 average daily attendance use the services of physicians, dentist, and psychiatrist in the school service performed by physicians, dentists, and psychiatrists employed by the school district should provide.
- Resource Type:
- Thesis
- Identifier:
- ocm58601144
- Campus Tesim:
- Fresno
- Creator:
- Gil, Joseph Young
- Description:
- The purpose of this study was to determine the prevalence myofascial trigger points (TPs) in asymptomatic overhead athletes. Glenohumeral rotation range of motion (ROM) of fifteen participants was measured on both the dominant and non-dominant arm. Following the ROM measures a second examiner, blinded to the ROM measurements, palpated for seven TPs in four muscles of the posterior shoulder: the posterior deltoid (1 TP), infraspinatus (3TPs), teres minor (1 TP), and latissimus dorsi (2 TP). These muscles apply braking force to assist in the deceleration of the upper extremity in order to prevent translation of the proximal humerus at the glenoid fossa (Borsa, Laudner, & Sauers, 2008). Chi-square tests were used to assess differences in prevalence of MTrPs between dominant and non-dominant arm. An alpha level of .05 was set a priori for all tests of significance. All analyses will be done with SPSS (V. 21, Chicago, IL). No significant differences (P>.05) were found between dominant and non-dominant arm, although a trend was noted with the trigger point identified in the infraspinatus (superior), which yielded a P value of 0.069. The results suggest a relationship between decreased ROM and the prevalence of trigger points. All the participants had at least one trigger point. The assessment and treatment of trigger points may be necessary when examining the shoulder for potential injury and (or) decrease in performance.
- Resource Type:
- Thesis
- Identifier:
- .b67027465
- Campus Tesim:
- Fresno
- Department:
- Kinesiology
- Creator:
- Matheson, Lonnie
- Description:
- The purpose of this study was to determine if the amount of learning from a teacher demonstration was significantly different from the learning achieved from a demonstration presented by closed-circuit video-taped television. All tests were conducted at the .01 level of confidence.
- Resource Type:
- Thesis
- Identifier:
- ocm61185066
- Campus Tesim:
- Fresno
- Department:
- Industrial Technology
- Creator:
- Berrettini, Mae
- Description:
- The purposes of the project were (1) to develop and demonstrate a plan for a community-sponsored preschool hearing screening program which could be implemented in a selected community; the requirements to be placed on the program were that both the administration and the actual screening be performed by trained, nonprofessional volunteers from a community which provided the necessary space, equipment, and publicity; (2) to benefit the children of the community by providing a service not offered by any other group or agency at this time; (3) to provide a basis for considering the development of a permanent service in other community; and (4) to serve as a guide for planning future preschool hearing screening programs in other communities with smaller or larger populations than the one used for this project.
- Resource Type:
- Thesis
- Identifier:
- ocm57365293
- Campus Tesim:
- Fresno
- Department:
- Communicative Disorders and Deaf Studies
- Creator:
- Salazar, Andrea Guadalupe
- Description:
- Latinos are the fastest growing ethnic minority in the United States; however statistics indicate that their college education attainment is not increasing proportionately to other ethnic groups. This study examined college aspirations, generational status, socioeconomic status (SES), perceived parental support, and gender influences among Latino and Euro- American fifth grade students (N=111). The student sample consisted of 78% Latino and 22% Euro-American students. All participants completed a demographic and college aspiration questionnaire and 17% of the students completed a face-to-face interview regarding college aspirations. It was predicted that there would be a significant difference between the college aspirations of Latino and Euro-American elementary school students; this was found in the total sample but was not found in the analysis of Latino and Euro-American students from the higher SES school. It was also hypothesized that perceived parental support would be positively related to students� college aspirations, which was supported for both Latino and Euro- American students. Interestingly, gender differences in college aspirations were not found among Latino or Euro-American elementary school students. Implications and future directions are discussed.
- Resource Type:
- Thesis
- Campus Tesim:
- Fresno
- Department:
- Art and Design
- Creator:
- Segal, Maurice
- Description:
- The purpose of Mils study was threefold? (1) to survey and examine the course content in the perspective drawing program being taught in eighty-two junior colleges in the State of California, (2) to survey the acceptability and desirability of a suggested course of instruction for a full semester foundation course in perspective drawing, and (3) to study the qualifications of the teachers. An investigation of junior college catalogues indicated from one to four courses, varying in title and description, being offered In architectural drafting. As one reviews the varying course descriptions, he finds very little information regarding perspective drawing. It became evident to the investigator that a course of instruction was needed for a formal foundation course in perspective drawing.
- Resource Type:
- Thesis
- Identifier:
- ocm62521660
- Campus Tesim:
- Fresno
- Department:
- Industrial Technology
- Creator:
- Farley, Jack Winfield
- Description:
- It is the purpose of this study to (1) give a comprehensive statement of the form and style to be employed in an experimental theater production of Eugene O'Neill's play Anna Christie, (2) show the motivation for the selection of a particular for and style, and (3) describe the circumstances which further influence any decisions concerning plans for production.
- Resource Type:
- Thesis
- Identifier:
- ocm58481794
- Campus Tesim:
- Fresno
- Department:
- Communication
- Creator:
- Anderson, Andrew
- Description:
- The objective was to determine the general shape of the curve describing the power-velocity relationship of skeletal muscle during cycle ergometry and determine the influence of muscle fiber type on mechanics of power production. 16 males volunteered and gave informed consent. A familiarization session was conducted in which subjects received training, and measurements (height, weight, 7-site skinfolds) were taken. The subject pool was divided into fast-twitch and slow-twitch subgroups based on a Thorstensson Fatigue Test. Other tests included max pedaling speed with no resistance, and power output and pedaling speed during a series of 12 6-s Wingate-types tests with resistances of 85 ? 195 gr/Kg LBM. Order of resistances was random, and 3 min of active recovery was allowed between tests. Testing was divided into two sessions so that subjects performed six power tests on separate days. Other variables were maximum power output, and relative pedaling velocity. Results showed that the FT subgroup produced greater Max RPM, but less Max Power than the ST subgroup. These differences were not statistically significant. The shape of the power-velocity curve was expected to be parabolic, but instead had two peaks. This pattern was in the curve constructed with data from all subjects and in the curves constructed with data from the subgroups. The peaks for ST occurred at 105 and 145 gr/Kg LBM and at 115 and 155 gr/Kg LBM for FT. It was concluded that in fit males, maximum power is produced at resistances ranging from 105 to 155 gr/Kg LBM, and that a higher percentage of FT fibers tends to produce Max Power at higher resistances.
- Resource Type:
- Thesis
- Identifier:
- .b68333791
- Campus Tesim:
- Fresno
- Department:
- Kinesiology