The following scheduling problem is studied: We are given a set of tasks with release times, deadlines, and profit rates. The objective is to determine a 1-processor preemptive schedule of the given tasks that maximizes the overall profit. In the stan . . .

High-fat feeding activates components of the pro-inflammatory pathway and increases co-immunoprecipitation of suppressor of cytokine signalling (SOCS)-3 with both the insulin receptor (IR)-β subunit and IRS-1, which together contribute to keeping PI-3 . . .

Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats. Am J Physiol Endocrinol Metab 280: E130-E142, 2001.—In addition to suppressing appetite, leptin may also modulate insulin secretion and actio . . .

During the Late Cretaceous to early Cenozoic, southern California was impacted by two anomalous tectonic events: (1) underplating of the oceanic Pelona-Orocopia-Rand schists beneath North American arc crust and craton; and (2) removal of the western m . . .

The serine/threonine protein kinase, mammalian target of rapamycin (mTOR) is regulated by insulin and nutrient availability and has been proposed to play a central role as a nutrient sensor in skeletal muscle. mTOR associates with its binding partners . . .

Chronic metabolic diseases develop from the complex interaction of environmental and genetic factors, although the extent to which each contributes to these disorders is unknown. Here, we test the hypothesis that artificial selection for low intrinsic . . .

doi:10.1152/ajpregu.00117.2009.—Suppressor of cytokine signaling (SOCS) proteins and/or activation of the proinflammatory pathway have been postulated as possible mechanisms that may contribute to skeletal muscle insulin resistance. Thus, the aims of . . .

AIMS: We evaluated if selected pro-inflammatory cytokines and/or the protein suppressor of cytokine signaling 3 (SOCS-3) could account for decreased insulin-stimulated phosphatidylinositol 3-kinase (PI3-K) activity in the skeletal muscle of the obese . . .

High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKK / phosphorylation and decreases PI-3 kinase activity in muscle. Am J Physiol Regul Integr Comp Physiol 296: R1709-R1715, 2009. First published April 22, 2009

To examine the evolution of endurance-exercise behaviour, we have selectively bred four replicate lines of laboratory mice (Mus domesticus) for high voluntary wheel running (`high runner' or HR lines), while also maintaining four non-selected control . . .