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ArticleHigh-Fat Diet And Leptin Treatment Alter Skeletal Muscle Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity And Glucose TransportYaspelkis III, Benedict B.The aim of this investigation was to evaluate if leptin treatment enhances insulin-stimulated glucose transport in normal (experimental group [EXP]-1) and insulin-resistant skeletal muscle (EXP-2) by altering components of the insulin-signaling cascad . . .
ArticleInsulin" stimulated plasma membrane association and activation of Akt2, aPKC ζ and aPKC λ in high fat fed rodent skeletal muscleReeder, Donald W.Several recent reports using cell lines have suggested that both Akt and atypical protein kinase C (aPKC) ζ/λ are translocated to the plasma membrane (PM) in response to insulin. However, it has yet to be determined in skeletal muscle whether: (1) ins . . .
ArticleLipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5"�-aminoimidazole-4-carboxamide-1-β-D-ribofuranosideHawley, J.AThe serine/threonine protein kinase, mammalian target of rapamycin (mTOR) is regulated by insulin and nutrient availability and has been proposed to play a central role as a nutrient sensor in skeletal muscle. mTOR associates with its binding partners . . .