Silent most of the year, giant pandas (Ailuropoda melanoleuca) engage in sustained and diverse vocal behavior during their brief annual reproductive window. These vocalizations suggest a complex communication repertoire and play an important role in f . . .

Southern California is a semi-arid ecosystem, in which a majority of streams are ephemeral and intermittent. By increasing water loads via anthropogenic water sources, these rivers may become perennial. Altering a river’s hydrological regime from an e . . .

Global positioning system (GPS) radio collars with very high frequency (VHF) beacons were deployed on 12 female southern mule deer (Odocoileus hemionus fuliginatus) within a 30,400 ha study area on the desert slopes of the Peninsular Rangers of southe . . .

Large amounts of nitrogen (N) are being deposited in urban areas of southern California, which are altering the carbon (C) and N cycling of semi-arid shrubland ecosystems. It is possible that these N inputs are exceeding biotic demand, leading to “N s . . .

Phosphoenolpyruvate carboxykinase catalyzes the nucleotide dependent reversible decarboxylation of oxaloacetate to phosphoenolpyruvate. PEPCK plays a variety of important roles in central and intermediary metabolism in organisms from all three domains . . .

Pathogens are constantly challenging the immune system and infection with multiple parasites simultaneously is common in nature. I examined a murine helminth/virus coinfection model, and infected mice with either Heligmosomoides bakeri or lymphocytic . . .

Life exists in a wide range of environments with prokaryotic organisms inhabiting those considered most hostile, including extremes of temperature, salinity, water activity, and pH. The microorganisms that inhabit these extreme environments, and in pa . . .

The Investigation of Specific Genetic Alleles and External Factors as a Determinant of Increased Neural Cell Cytotoxicity in Alzheimer ’s Disease VALA Sciences Cherie Handley Professional Master’s Degree Program Cal State University San Marcos Objecti . . .

The goal of this Semester-In-Residence Project was to continue the business plan presented by Mahva Naghipor and Robert Iddings. Market research was to be conducted by surveying the San Diego life science community to determine the availability of don . . .

Objective: This Semester-in-Residence Project was conducted at the California State University, San Marcos, Extended Learning. CSUSM plans to develop an innovation hub in the new Extended Learning’s 135,000 sq. ft, six story building located on the no . . .

Executive Summary The technology in electrical and electronic equipment progresses rapidly which leads to a shortened product lifecycle, thus resulting in increased electrical and potentially hazardouschemicalwaste. Additionally, an increased amount o . . .

Agragene, a San Diego based startup, is pursuing a novel precision guided sterile insect technology for the invasive, agricultural pest species, Drosophila suzukii. There is no regulatory precedent for commercial approval of a similar technology. For . . .

This Semester-In-Residence (SIR) program was completed at Navigate Biopharma Services, Inc., a Novartis subsidiary located in Carlsbad, CA. Navigate Biopharma Services specializes in providing services to various companies including assay development, . . .

This project was conducted for Rare Science, a non-profit organization that works directly with patient families and foundations to accelerate therapeutic solutions for children with rare diseases. Introduction The famous philosopher once said, “Rare . . .

GenMark Dx is a molecular diagnostics company focused on multiplex tests that diagnose complex medical conditions. GenMark’s eSensor technology is based on DNA hybridization and electrochemical detection. The ePlex platform is capable of performing sa . . .

BioSpark Laboratories is a proposed non-profit organization intended to serve scientific researchers in South America by providing low cost laboratory equipment. Based out of San Diego, BioSpark takes advantage of the vast diversity of life science in . . .

This Semester-in-Residence project was conducted at Gilead Sciences, Biopharmaceutical Company, in Oceanside, CA within manufacturing department. The goal of the project was to generate User Requirement Specifications (URS), Standard Operating Procedu . . .

This project was conducted at a clinical oncology laboratory specializing in hematology and solid tumors. This was a cross functional collaboration between marketing and flow cytometry. The goal of the project was to become more competitive, increase . . .

This project is working in conjunction with the Let’s Go Robotics, Incorporated (LGR) to investigate the performance efficacy of its new product: mini automated liquid handling (ALH) Precise Drop ™ system. With the flourish of the biotech industries, . . .

Currently, the San Diego Police Department Forensics Biology Unit utilizes the AmpFlSTR® YFiler PCR Amplification Kit from Applied Biosystems. However, they have been looking to upgrade to the new YFiler Plus Amplification Kit from Thermo Fisher Scien . . .

Although many advances in research for the identification of infections have been made, Sepsis stands as one of the leading causes of death in the United States3. Sepsis is life threatening since it causes organ dysfunction caused by a deregulated imm . . .

Executive Summary Cleanroom Training to Decrease Deviations Related to Process Error and Operator Error Ajinomoto Althea Inc. Jaycee Nguyen 04 May 2017 Professional Master's Degree Program California State University, San Marcos During Spring 2017 Sem . . .

Curli are proteinaceous fibers assembled by enteric bacteria (E. coli, Salmonella). These curli fibers are thought to be involved in cell adhesion, aggregation, and the formation of biofilms. The formation of curli fibers is thought to involve six pro . . .

This project aims to reduce the product heterogeneity of Mab1 for improving its product profile by genetically removing the c-terminal lysine on Mab1. Using PCR, the DNA encoding heavy chain without the terminal lysine is amplified and cloned into the . . .

This Spring 2017 Semester-in- Residence was conducted at Ajinomoto Althea, Inc. in the Process Science department located in San Diego, CA. Ajinomoto Althea, Inc. (also known as, “Althea”) is a contract manufacturing organization known for providing c . . .

Reprogramming techniques based on Sendai virus have emerged as the gold-standard method for induced pluripotent stem cells (iPSC) generation due to its consistency and efficiency in reprogramming somatic cells from diverse genetic background in differ . . .

Since the discovery of Induced pluripotent stem cells (iPSCs) a decade ago, they have become widely used in regenerative medicine and with iPSC development becoming easier over the past years, it is possible for patient samples to be used for autologo . . .

Enteric bacteria such as Escherichia Coli and Salmonella produce a type of proteinaceous cell surface filament known as curli. These fibers are an adaptation that enable these bacteria to survive certain environmental conditions, to mediate host cell . . .

Genentech is a biopharmaceutical company located in Oceanside, CA. The Oceanside campus is one of five locations within the United States and is a multi-product drug substance Manufacturing facility of biopharmaceuticals. The Manufacturing production . . .

Company X, Oceanside campus, is a bioprocessing company that manufactures biologics to treat patients with life threatening and serious medical conditions. With large number of new hires onboarding and a current expansion of its manufacturing facility . . .

EXECUTIVE SUMMARY Calibration and Testing Electrodes for Use in a Fertigation System Jack Hattaway 8/3/2016 Professional Master’s Degree Program California State University at San Marcos The Fertigation Monitoring System (FERM-SYS) is designed to cont . . .

Methicillin Resistant Staphylococcus aureus (MRSA) is one of the leading causes of Hospital Acquired Infections (HAIs) and is notorious for its high mortality rate. Many multiplex assays to detect MRSA are currently in the market but are either expens . . .

This project worked in conjunction with the Kinesiology Department’s Surf Research initiative to investigate the effects of volume distribution of a surfboard on metabolic efficiency for the avid surfer. There are large populations of surfers in the U . . .

This project was conducted at Neuropore Therapies, Inc. Neuropore is located in San Diego, CA and the business focus is on curing neuro-degenerative diseases, namely Parkinson’s Disease and Alzheimer’s Disease. Project goals included becoming certifie . . .

Active Motif, an epigenetics company based in Carlsbad, develops and delivers tools to facilitate the study of epigenetics and gene regulation. In this field, DNA methylation is hallmark of cancer. In mammals and other vertebrates DNA methylation occu . . .

Clostridium difficile frequently causes infectious diarrhea in hospitalized and elderly people. Infection results from reduction of natural intestinal flora, allowing the spores to grow and spread via fomites. The severity of C. difficile infection de . . .

Thermo Fisher Scientific is currently developing a diagnostic assay using the Ion Torrent™ next-generation sequencing platform for the genetic testing of cancer variants. The assay is comprised of two sets of primer panels to simultaneously screen app . . .

One major challenge for current medical and scientific approaches to understanding, characterizing, and treating the more than six hundred described neurological disorders in humans is lack of access to neural tissue. Difficulty in ethically obtaining . . .

The Semester-in-Residence project was an academic research oriented project conducted through California State University San Marcos. Computing resources was initially provided by a Linux computer cluster located on campus and the bulk of the analysis . . .

This Semester-in-Residence (SIR) Project was conducted with the sponsorship of T2 Energy LCC. Located in Vista, California, T2 Energy is an algae carbon capture technology company that has developed novel techniques for the growth and harvesting of al . . .

This Semester-in-Residence Project was conducted at Company N on behalf of the Quality Assurance Department. Company N is a biological substance manufacturing facility. In order for Company N to manufacture and distribute product, each product lot is . . .

Biologists now realize that there is more to understanding various diseases than just looking at the DNA sequence of a gene. For this reason, the study of epigenetics has grown exponentially in regards to peer reviewed articles over the last decade. T . . .

Executive Summary Cost Analysis of Terminal Sterilization and Aseptic Processing Methods of Sensitive Implantable Combination Drug Device Products Company X Zenabu Bawa-Mamudu – 4/24/2015 Professional Science Master’s in Biotechnology, California Stat . . .

Multiplexing Asymmetric Primer Extension is a complex and lengthy reaction that can be affected by many variables. It is used by AutoGenomics Inc. to help determine patient’s genetic mutations that could affect their course of treatment and to determi . . .

Genentech, Oceanside is a biopharmaceutical manufacturing plant with bioprocessing technicians that have a large range of experience and education in biotechnology. Before, Genentech, Oceanside did not have a training plan for experienced bioprocess t . . .

Controlling interferon production will reduce the frequency of relapses of multiple sclerosis and provide a better quality of life for patients. Finding the gatekeepers within the pDC pathway that controls IFN production will lead to therapeutic devel . . .

Astaxanthin is a high-value red carotenoid pigment commonly used in the food, feed and cosmetics industries due to its well-known antioxidant, anti-inflammatory and antitumor properties. The unicellular microalga Haematococcus pluvialis is one of the . . .

This research project was sponsored by the marketing department at Company X. As flow cytometry experiments become increasingly complex, researchers need tools and products dedicated to making experimental design as efficient as possible. For example, . . .

Preserving the genetic material of exotic species is essential to maintain genetic diversity and to ensure the survival of captive populations. In this project, chicken fibroblast (FB) nuclei are inserted into inactivated avian germline stem cells (GS . . .

Preserving the genetic material of exotic species is essential to maintain genetic diversity and to ensure the survival of captive populations. In this project, chicken fibroblast (FB) nuclei are inserted into inactivated avian germline stem cells (GS . . .