We previously reported that triggered Ca waves (TCWs) occur in dog atrial myocytes during rapid pacing. The goal of this study was to investigate the effect of TCWs on APs during rapid pacing in left atrial myocytes from both normal and failing hearts . . .

Spontaneous Ca2+ release (SCR) in the form of Ca2+ waves is responsible for cardiac myocyte depolarization and delayed afterdepolarizations (DADs) that can produce triggered beats. Whether or not a cell reaches threshold is determined by the magnitude . . .

Background: Abnormalities in intracellular calcium (Ca) cycling during Ca overload can cause triggered activity because spontaneous calcium release (SCR) activates sufficient Ca-sensitive inward currents to induce delayed afterdepolarizations (DADs). . . .

Background: Abnormalities in intracellular calcium (Ca) cycling during Ca overload can cause triggered activity because spontaneous calcium release (SCR) activates sufficient Ca-sensitive inward currents to induce delayed afterdepolarizations (DADs). . . .

Excitation-contraction coupling in atrial cells is mediated by calcium (Ca) signaling between L-type Ca channels and Ryanodine receptors that occurs mainly at the cell boundary. This unique architecture dictates essential aspects of Ca signaling under . . .

Aims: Abnormal intracellular Ca2+ cycling contributes to triggered activity and arrhythmias in the heart. We investigated the properties and underlying mechanisms for systolic triggered Ca2+ waves in left atria from normal and failing dog hearts.Metho . . .

Among the most important decisions an animal makes is whether to engage in active movement and feeding behavior or to become quiescent. The molecular signaling mechanisms underlying this decision remain largely unknown. The nematode Caenorhabditis ele . . .

Clinical studies have shown that sudden death is initiated by an ill-timed propagated ectopic beat that leads to fibrillation.1-4 However, the mechanism underlying these focal excitations is not completely understood. Experimental studies have demonst . . .

In cardiac myocytes, calcium (Ca) can be released from the sarcoplasmic reticulum independently of Ca influx from voltage-dependent membrane channels. This efflux of Ca, referred to as spontaneous Ca release (SCR), is due to Ryanodine receptor fluctua . . .

Intracellular Ca waves occur as the result of spontaneous Ca release (SCR) during Ca overload. Ca waves activate Na-Ca exchange, causing delayed afterdepolarizations (DAD) which can achieve threshold and produce triggered extrasystoles. It is not know . . .