The L-type Ca current (ICa,L), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking ICa,L can prevent ventricular fibrillation, but only at levels suppressing co . . .

It is well documented that parasympathetic stimulation leads to atrial arrhythmias. Because acetylcholine abolishes the dome portion of an action potential (AP), phase 2 reentry (P2R), reentry due to propagation of the dome of an AP from areas with th . . .

Mathematical modeling of the cardiac action potential has proven to be a powerful tool for illuminating various aspects of cardiac function, including cardiac arrhythmias. However, no currently available detailed action potential model accurately repr . . .

In homogenous tissue, conduction velocity restitution (CVR) is required for the development of spatially discordant alternans (SDA) except after an ectopic beat. We hypothesized that global capture of monolayers would eliminate CV gradients and SDA wo . . .

Ventricular fibrillation (VF) is characterized by multiple reentrant waves promoted by both dynamical instabilities and anatomical heterogeneities. Decreasing dynamic wave instability by flattening action potential duration restitution (APDR) slope wi . . .

Ventricular fibrillation (VF), a leading cause of sudden cardiac death, is due multiple re-entrant waves created as a result of spiral wave break-up. Dynamic wave instabilities can cause spontaneous wavebreak, leading to a fibrillation like state even . . .

The mechanism of initiation of ventricular fibrillation (VF) in normal and diseased heart is poorly understood. It has been shown that VF starts with a simple reentry, or ventricular tachycardia (VT), which then degenerates into the multiple meanderin . . .