The L-type Ca current (ICa,L), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking ICa,L can prevent ventricular fibrillation, but only at levels suppressing co . . .

Previous studies have demonstrated that the slope of the function relating the action potential duration (APD) and the diastolic interval, known as the APD restitution curve, plays an important role in the initiation and maintenance of ventricular fib . . .

Mathematical modeling of the cardiac action potential has proven to be a powerful tool for illuminating various aspects of cardiac function, including cardiac arrhythmias. However, no currently available detailed action potential model accurately repr . . .

In homogenous tissue, conduction velocity restitution (CVR) is required for the development of spatially discordant alternans (SDA) except after an ectopic beat. We hypothesized that global capture of monolayers would eliminate CV gradients and SDA wo . . .

Ventricular fibrillation (VF), a leading cause of sudden cardiac death, is due multiple re-entrant waves created as a result of spiral wave break-up. Dynamic wave instabilities can cause spontaneous wavebreak, leading to a fibrillation like state even . . .