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Filtering by: Creator Pawelek, John M. Remove constraint Creator: Pawelek, John M.

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  • Work
    Book chapter
    Murray, Sean R.
    Tumor-targeted Salmonella offers a promising approach to the delivery of therapeutics for the treatment of cancer. The Salmonella strains used, however, must be stably attenuated in order to provide sufficient safety for administration. Approaches to . . .
  • Work
    Article
    Bermudes, David
    Live bacteria were first actively used in the treatment of cancer nearly 150 years ago, work that ultimately led to the study of immunomodulation. Today, with the discovery of bacterial strains that specifically target tumours, and aided by genomic se . . .
  • Work
    Article
    Lin, Stanley
    Systemically administered tumor-targeted Salmonella has been developed as an anticancer agent, although its use could be limited by the potential induction of tumor necrosis factor ? (TNF?)-mediated septic shock stimulated by lipid A. Genetic modifica . . .
  • Work
    Book chapter
    Pawelek, John M.
    Genetically engineered Salmonella offer an intriguing new approach to selectively target solid tumors, including melanoma, lung, colon, breast, kidney and liver. These bacteria target tumors after systemic administration and selectively replicate with . . .
  • Work
    Article
    Chakraborty, Ashok
    Studies were conducted on the hypothesis that melanoma metastasis might be initiated through the gener-ation of hybrids comprised of cells of the primary tumor and tumor-infiltrating leukocytes. Fusion hybrids were generated in vitro between weakly me . . .
  • Work
    Article
    Bermudes, David
    Live bacteria were first actively used in the treatment of cancer nearly 150 years ago, work that ultimately led to the study of immunomodulation. Today, with the discovery of bacterial strains that specifically target tumours, and aided by genomic se . . .
  • Work
    Article
    Pawelek, John M.
    There has been little investigation of bacteria as gene delivery vectors. Here, we demonstrate that genetically engineered Salmonella have many of the desirable properties of a delivery vector, including targeting of multiple tumors from a distant ino . . .