In pancreatic ductal adenocarcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits integrin and growth factor signals mediated by the tumor microenvironment. Alth . . .

The cell cytoskeleton is composed of microtubules, intermediate filaments, and actin, which provide a rigid support structure important for cell shape. However, it is also a dynamic signaling scaffold that receives and transmits complex mechano-sensin . . .

Deregulation of protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression. eIF5A1 and its highly related isoform eIF5A2 are translation initiation factors that have been implicated in a range of human malignanc . . .