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Filtering by: Creator Zelaya, Ligia

Thesis

Synthesis of Fluorogenic Phosphatidylcholine Derivatives for Kinetic Studies of Phospholipase A2 Enzymes

Zelaya, Ligia

Secretory phospholipase A2 (sPLA2) represents a class of enzymes that catalyze the hydrolysis of the sn-2 ester linkage of glycerophospholipids to generate bioactive lipid mediators that include lysophospholipids and fatty acids. These bioactive lipid . . .
Article

Activity-based targeting of secretory phospholipase A2 enzymes: A fatty-acid-binding-protein assisted approach

Ranganathan, Radha

Syntheses and enzymological characterization of fluorogenic substrate probes targeting secretory phospholipase A2 (sPLA2) for detection and quantitative assays are presented. Three fluorogenic phosphatidylcholine analogs PC-1, PC-2, and PC-3 each cont . . .