ThesisSynthesis of Fluorogenic Phosphatidylcholine Derivatives for Kinetic Studies of Phospholipase A2 EnzymesZelaya, LigiaSecretory phospholipase A2 (sPLA2) represents a class of enzymes that catalyze the hydrolysis of the sn-2 ester linkage of glycerophospholipids to generate bioactive lipid mediators that include lysophospholipids and fatty acids. These bioactive lipid . . .
ArticleActivity-based targeting of secretory phospholipase A2 enzymes: A fatty-acid-binding-protein assisted approachRanganathan, RadhaSyntheses and enzymological characterization of fluorogenic substrate probes targeting secretory phospholipase A2 (sPLA2) for detection and quantitative assays are presented. Three fluorogenic phosphatidylcholine analogs PC-1, PC-2, and PC-3 each cont . . .