Chronic wounds are a growing problem caused by increases in the incidence of diabetes, obesity, and the aging population, and they represent a disproportionately large burden to the healthcare system. The risk of complications including infections tha . . .

We have used a tetracycline controlled transcriptional activation system, known as tet-off, as a novel reporter system that demonstrates the capacity of Mesenchymal stem cells (MSCs) to transfer siRNA. Traditionally, knockdown systems using siRNA are . . .

Acute lymphoblastic leukemia is the most common malignancy diagnosed in children. High-risk leukemia patients have poor outcomes despite advancements in chemotherapy treatments. Due to current therapy dose limitations, toxicities to normal cells, long . . .

Ductal Carcinoma In Situ (DCIS) is considered the earliest form of breast cancer where cells that appear malignant develop into benign heterogneous lesions confined within the epithelial membrane, yet progression to invasive ductal carcinoma frequentl . . .

Human Immunodeficiency Virus (HIV) and the subsequent acquisition of Acquired Immunodeficiency Syndrome (AIDS) continues to affect millions of lives around the world with no effective vaccine available. Current antiretroviral treatments are effective . . .

Stem cells can divide indefinitely and maintain their capability to differentiate into many cell types, the key features of self-renewal and pluripotency, which explains their importance to regenerative medicine. Embryonic stem cells (ESCs), the most . . .

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a genetic disease characterized by impaired movement coordination, peripheral nervous system damage, limb tremors, cognitive decline, behavioral changes, autonomic nervous system dysfunction, inte . . .

Liver disease is one of the leading causes of death worldwide, and over 25,000 people per year die in the U.S. Often the only option available for liver disease patients is liver transplantation, however, liver transplantation is severely limited due . . .

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease. Each year, about 5,000 people in the US are diagnosed with ALS. Treatment options for ALS patients are very limited with only one FDA approved drug that extends sur . . .

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult onset neurodegenerative disorder affecting carriers of premutation expansions (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene. The clinical features of FXTAS, as we . . .