Ricerca
1 termine di ricerca trovato
Risultati della ricerca
- Creatore:
- Tuschka, Ted.
- Descrizione:
- Grewe' s synthesis of the morphine ring system has
been applied by May to the synthesis of benzomorphan (2,3).
In his scheme the diene which resulted from the treatment
of a pyridinium salt with a Grignard reagent was catalyti-
cally hyarogenated, leaving a single double bond. Subse-
quent ring closure formed benzomorphan. It was the purpose
of this research to react the diene intermediate of May's
in a Diels Alder cycloaddition. The resulting adduct was
then reacted in a Friedel Crafts addition to the aromatic
center by analogy to May's scheme. This ring closure could
be accomplished only by treatment with 48% hydrogen bromide;
the other methods described by May (4) caused a cyclorever-
sion of the Diels Alder adduct. The resulting carbon
skeleton will hopefully be the source of an analgesic similar
to morphine.
- Resource Type:
- Masters Thesis
- Campus Tesim:
- Fresno
- Department:
- Chemistry