Filtering by: Publisher Proceedings of the National Academy of Sciences of the United States of America Remove constraint Publisher: Proceedings of the National Academy of Sciences of the United States of America
ArticleActivation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonistsGuthrie, BrianThe sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor (GPCR), which belongs to the class C family that also includes the metabotropic glutamate and γ-aminobutyric acid receptors. We report here the predicted 3D structur . . .
ArticleBrown, James H.Natural ecosystems contain many individuals and species interacting with each other and with their abiotic environment. Such systems can be expected to exhibit complex dynamics in which small perturbations can be amplified to cause large changes. Here . . .
ArticleHarris, Francis L.The present study determined the effect of organically quaternizing either of the two tertiary nitrogen sites of nicotine to assess the in vivo effects of the permanently ionized states of the synthesized N-[14C]methylnicotines on brain uptake in rat . . .