Regulation of membrane trafficking requires the concerted actions of rab proteins, their effectors and several phosphatidylinositol 3??kinases. Rab7 is required for late endosomal transport and here we establish that the phosphatidylinositol 3??kinase . . .

Myotubularins constitute a ubiquitous family of phosphatidylinositol (PI) 3-phosphatases implicated in several neuromuscular disorders. Myotubularin [myotubular myopathy 1 (MTM1)] PI 3-phosphatase is shown associated with early and late endosomes. Los . . .