ThesisDevelopment of an elisa protocol for the conformation-specific quantification of the pro-apoptotic protein baxUrtecho, J.B.Apoptosis is the cell’s primary response to stress, and is one of the body’s most important lines of defense against cancer. The process is initiated and governed by the Bcl-2 family of regulatory proteins, which contains both pro- and anti-apoptotic . . .
ThesisThe Role of N-Terminal Domain Exposure of Bax in the Regulation of Intrinsic Apoptosis at the MitochondriaFriedlein, Jordan BradleyThe Bcl-2 protein family, made up of pro and anti-apoptotic proteins plays a major role in regulating apoptosis. Bax is a pro-apoptotic member of the Bcl-2 family. In its inactive form, Bax is primarily a cytosolic and monomeric protein. Upon activati . . .