Objectives. 1. To determine the presence of mesenchymal stem cells (MSC) in rat embryo limb buds and adult rat knee joints. 2. To determine the pharmacological effects of recombinant human GDF-5 (rhGDF-5) on rat MSCs. 3. To determine the effect of rhG . . .

The existence of cancer stem cells (CSC) postulates that tumors are organized as a cellular hierarchy and that tumor initiation, growth and cellular heterogeneity are driven by a subset of cells with stem cell like properties. The CSCs are endowed wit . . .

Bone graft substitutes are commonly used as an alloplastic source for complex bone repair. Human mesenchymal stem cells (hMSCs) have become an idealistic source for bone repair and regeneration due to their potential to differentiate into osteogenic p . . .