Ketamine and dextromethorphan belong to the drug class known as dissociatives. They produce several behavioral effects, including dissociation from self and disruptions in learning and memory. Initiation of dissociative use is often in adolescence, an . . .

Over the last decade, a number of studies have demonstrated that ketamine has immediate and long-lasting antidepressant effects in humans and rodent models of depression. However, our lab and others have been unable to replicate these effects using th . . .