Molecular-level investigation of proteins is increasingly important to researchers trying to understand the mechanisms of signal transmission. Heterotrimeric G proteins control the activation of many critical signal transmission cascades and are also . . .

A new approach is presented for determining the rigid regions in proteins and the flexible joints between them. The short-range forces in proteins are modeled as constraints and we use a recently developed formalism from graph theory to analyze flexib . . .

AdoMet radical enzymes are involved in processes such as cofactor biosynthesis, anaerobic metabolism, and natural product biosynthesis. These enzymes utilize the reductive cleavage of S-adenosylmethionine (AdoMet) to afford L-methionine and a transien . . .

Species pairs that differ primarily in characters involved in mating interactions and are largely sympatric raise intriguing questions about the mode of speciation. When species divergence is relatively recent, the footprint of the demographic history . . .

We demonstrate that biological molecules such as Watson–Crick DNA base pairs can behave as biological Aviram–Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases. We have performed a parallel . . .

In a recent Letter, Choi et al. performed first-principles GW-Bethe-Salpeter equation ( GW-BSE) calculations for a number of two-dimensional (2D) semiconductors and discovered a linear scaling relation between exciton binding energy Eb and quasipartic . . .

Many reports qualitatively describe conserved stability and flexibility profiles across protein families, but biophysical modeling schemes have not been available to robustly quantify both. Here we investigate an orthologous RNase H pair by using a mi . . .

Recent numerical results on classical dimers with weak aligning interactions have been theoretically justified via a Coulomb gas representation of the height random variable. Here, we propose a completely different representation, the interacting ferm . . .

The B-lymphocyte accessory molecule Ig-alpha (Ig-?) is encoded by the mouse B cell-specific gene (mb-1), and along with the Ig-beta (Ig-?) molecule and a membrane bound immunoglobulin (mIg) makes up the B-cell receptor (BCR). Ig-? and Ig-? form a hete . . .

A statistical mechanical distance constraint model (DCM) is presented that explicitly accounts for network rigidity among constraints present within a system. Constraints are characterized by local microscopic free-energy functions. Topological rearra . . .