ThesisSynthesis of fluorescent phospholipid analogs for kinetic and mechanistic studies of phospholipase A2 enzymesKeshavarz, AmirThe synthesis and characterization of two fluorogenic phospholipase A2 enzyme substrates (PC-1, PC-2) have been accomplished. (R)-3-amino-1,2-propanediol was employed as the chiral precursor for synthesizing the optically active phospholipid molecules . . .
VideoCorella, April MelodyPhospholipase A2 (PLA2) enzymes catalyze hydrolysis of phospholipids present in the cellular membrane bilayer breaking them into fatty acids and lysolipids. These products perform physiological and patho-physiological functions. PLA2 activity has been . . .