ArticleHigh-Fat Diet And Leptin Treatment Alter Skeletal Muscle Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity And Glucose TransportCollins, Dale E.The aim of this investigation was to evaluate if leptin treatment enhances insulin-stimulated glucose transport in normal (experimental group [EXP]-1) and insulin-resistant skeletal muscle (EXP-2) by altering components of the insulin-signaling cascad . . .
ArticleThe Mouse B Cell-Specific Mb-1 Gene Encodes An Immunoreceptor Tyrosine-Based Activation Motif (Itam) Protein That May Be Evolutionarily Conserved In Diverse Species By Purifying SelectionVandergon, Virginia OberholzerThe B-lymphocyte accessory molecule Ig-alpha (Ig-?) is encoded by the mouse B cell-specific gene (mb-1), and along with the Ig-beta (Ig-?) molecule and a membrane bound immunoglobulin (mIg) makes up the B-cell receptor (BCR). Ig-? and Ig-? form a hete . . .
ArticleLipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5"�-aminoimidazole-4-carboxamide-1-β-D-ribofuranosideHawley, J.AThe serine/threonine protein kinase, mammalian target of rapamycin (mTOR) is regulated by insulin and nutrient availability and has been proposed to play a central role as a nutrient sensor in skeletal muscle. mTOR associates with its binding partners . . .
ArticleSchedl, PaulThe specification of primordial germ cells (PGCs) and subsequent maintenance of germ-line identity in Drosophila embryos has long been thought to occur solely under the control of cell-autonomous factors deposited in the posterior pole plasm during oo . . .