ArticleShiferaw, YohannesSpontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac arrhythmias. However, to date, it . . .
ArticleWasserstrom, John A.Clinical studies have shown that sudden death is initiated by an ill-timed propagated ectopic beat that leads to fibrillation.1-4 However, the mechanism underlying these focal excitations is not completely understood. Experimental studies have demonst . . .
ArticleSynchronization of Spontaneous Calcium Release Waves Among Myocytes in Intact Heart Determines the Magnitude of Delayed Afterdepolarizations and Triggered ActivityAistrup, Gary L.Intracellular Ca waves occur as the result of spontaneous Ca release (SCR) during Ca overload. Ca waves activate Na-Ca exchange, causing delayed afterdepolarizations (DAD) which can achieve threshold and produce triggered extrasystoles. It is not know . . .