Spontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac arrhythmias. However, to date, it . . .

Clinical studies have shown that sudden death is initiated by an ill-timed propagated ectopic beat that leads to fibrillation.1-4 However, the mechanism underlying these focal excitations is not completely understood. Experimental studies have demonst . . .

Intracellular Ca waves occur as the result of spontaneous Ca release (SCR) during Ca overload. Ca waves activate Na-Ca exchange, causing delayed afterdepolarizations (DAD) which can achieve threshold and produce triggered extrasystoles. It is not know . . .