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Book chapterLow, K. BrooksTumor-targeted Salmonella offers a promising approach to the delivery of therapeutics for the treatment of cancer. The Salmonella strains used, however, must be stably attenuated in order to provide sufficient safety for administration. Approaches to . . . -
ArticleIttensohn, MartinaIn order to noninvasively detect Salmonella delivery vectors within tumors, we used a genetically modified Salmonella, VNP20009, that expresses the herpes simplex thymidine kinase (HSV1-tk) reporter gene. VNP20009-TK were able to selectively localize . . .
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ThesisHeterologous Expression and Secretion of Aggregatibacter Leukotoxin A by a Tumor-Targeted SalmonellaVincent, LenaDespite the advancement of numerous treatment options, conventional cancer therapeutics generally fail to prevent tumor recurrence or successfully treat metastatic cells. A promising alternative involves the use of attenuated Salmonella strains, which . . .
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Book chapterKing, Ivan C.The ideal anticancer regimen is one that is specific for cancer cells with limited toxicity to normal tissues. Genetically modified, nonpathogenic Salmonella offer a potential way to induce direct tumoricidal activity or to deliver tumoricidal agents . . .
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ArticleKing, Ivan C.Purpose: We engineered the oncolytic Salmonella typhimurium–derived bacterium VNP20009 as a vector to target delivery to tumors of the prodrug-activating enzyme carboxypeptidase G2 (CPG2) and to show enhanced antitumor efficacy on administration of di . . .
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ArticleRockwell, S.The antitumour efficacy of lipid A mutant Salmonella was evaluated alone and in combination with X-rays in mice bearing B16F10 or Cloudman S91 melanomas. Each treatment alone slowed tumour growth and prolonged survival, and the combined treatments pro . . .
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ArticleZheng, Li-MouAttenuated strains of Salmonella typhimurium, VNP20009 and YS7212, when injected systemically to tumor-bearing mice, accumulated preferentially in tumors at levels at least 200-fold and, more commonly, 1000-fold greater than in other normal tissues. T . . .
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ThesisKrage, Emily RoseThe reduction of Salmonella surrogate, Enterococcus faecium ATCC 8459, was evaluated in strip loins and ribeye rolls at internal temperatures lower than 54.4°C, to determine if a 6.5-log10 reduction could be achieved, as required by USDA-FSIS and demo . . .
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Masters ThesisHarrison, JustinThe addition of nutrients and fecal coliforms from grazing activities to stream systems has been of great concern to farmers, cattlemen, environmental agencies and advocates, and local citizens. The North Coast Regional Water Quality Board is in the p . . .
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PosterMagin, AshleyMicrobial contaminations in food and water may post a threat to public health. Ice is defined as a food by the U.S. Food and Drug Administration (FDA). According to the International Packaged Ice Association (IPIA), approximately 2 billion bags of ice . . .