ArticleHigh-Fat Diet And Leptin Treatment Alter Skeletal Muscle Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity And Glucose TransportCollins, Dale E.The aim of this investigation was to evaluate if leptin treatment enhances insulin-stimulated glucose transport in normal (experimental group [EXP]-1) and insulin-resistant skeletal muscle (EXP-2) by altering components of the insulin-signaling cascad . . .
ArticleInsulin" stimulated plasma membrane association and activation of Akt2, aPKC ζ and aPKC λ in high fat fed rodent skeletal muscleLimon, Jose J.Several recent reports using cell lines have suggested that both Akt and atypical protein kinase C (aPKC) ζ/λ are translocated to the plasma membrane (PM) in response to insulin. However, it has yet to be determined in skeletal muscle whether: (1) ins . . .
ArticleChronic Leptin Treatment Enhances Insulin-Stimulated Glucose Disposal In Skeletal Muscle Of High-Fat Fed RodentsKrisan, Adam DThe aim of this investigation was to evaluate if chronic leptin administration corrects high fat diet-induced skeletal muscle insulin resistance, in part, by enhancing rates of glucose disposal and if the improvements are accounted for by alterations . . .
ArticleLipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5"�-aminoimidazole-4-carboxamide-1-β-D-ribofuranosideHawley, J.AThe serine/threonine protein kinase, mammalian target of rapamycin (mTOR) is regulated by insulin and nutrient availability and has been proposed to play a central role as a nutrient sensor in skeletal muscle. mTOR associates with its binding partners . . .