Hypoxia stimulates human embryonic stem cell (hESC) self-renewal. It has been shown that hypoxia inducible factor 2α (HIF2α) up regulates OCT4 (POU5F1) transcription, a pluripotency marker gene. Hypoxia also increases the efficiency of reprogramming o . . .

Cell-based approaches utilizing hematopoietic stem cells (HSC) and T cells with naturally occurring, or experimentally introduced, genetic modifications that confer either HIV resistance or enhanced anti-HIV properties have emerged recently as viable . . .