Filtering by: Subject ventricular fibrillation Remove constraint Subject: ventricular fibrillation
ArticleModifying L-Type Calcium Current Kinetics: Consequences for Cardiac Excitation and Arrhythmia DynamicsShiferaw, YohannesThe L-type Ca current (ICa,L), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking ICa,L can prevent ventricular fibrillation, but only at levels suppressing co . . .
ThesisHernandez Hernandez, GonzaloSpontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac arrhythmias. However, to date, it . . .
Conference paper or proceedingsStochastic spontaneous calcium release events and sodium channelopathies promote ventricular arrhythmiasPlank, GernotWhen a cardiac cell is stimulated at rapid rates, the action potential duration (APD) can exhibit period-doubling oscillations referred to as "alternans", where the APD alternates in a long-short-long-short (LSLS) temporal pattern [1,2]. A number of s . . .
ArticleThe role of action potential duration restitution in vulnerability to reentry in a mathematical model of canine ventricleHayat-Davoudi, AshkanThe mechanism of initiation of ventricular fibrillation (VF) in normal and diseased heart is poorly understood. It has been shown that VF starts with a simple reentry, or ventricular tachycardia (VT), which then degenerates into the multiple meanderin . . .