Synthesis Of Oligo(Ethylene Glycol) Substituted Phosphatidylcholines: Secretory Pla2-Targeted Precursors Of Nsaid Prodrugs

A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo(ethyleneglycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by phospholipaseA2 yielded a series of oligo(ethyleneglycol)-conjugates of the respective drugs. The approach here outlined may open a new way to employ OEG derivatives of phospholipids for therapeutic applications as secretory PLA2-targeted precursors of prodrugs.