Nucleation of Calcium Waves in Cardiac Cells: The Role of Network Connectivity

Spontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac arrhythmias. However, to date, it is not understood what determines the timing and location of spontaneous calcium waves within cells. Here, we analyze a simplified model of SCR in which Ca release is modeled as a stochastic processes on a two dimensional network of randomly distributed sites.