Article

The Role And Expression Of Mir-100 And Mir-203 Profile As Prognostic Markers In Epithelial Ovarian Cancer

Purpose: The present study was aimed to evaluate the clinical significance of miR-1 and miR-23 in epithelial ovarian cancer (EOC) patients. Methods: The expression levels of miR-1/23 in EOC tissue and adjacent non-cancerous samples were determined by real-time RT-PCR. Associations between miRNAs expressions and various clinicopathological characteristics were analyzed. Survival rate was determined with Kaplan-Meier and statistically analyzed with the log-rank method between groups. Survival data were evaluated through multivariate. Cox regression analysis. Findings: Our findings showed that miR-1 was significantly down-regulated in EOC tissue specimens than in adjacent non-cancerous tissues. The expression level of miR-23 was significantly higher in EOC tissues compared to adjacent non-cancerous tissues. Decreased expression of miR-1 was strongly associated with high FIGO stage (P=.12). The high expression of miR-23 was significantly correlated with advanced FIGO stage (p=.6), advanced histological grade (p=.3). Kaplan-Meier analysis and log-rank test have suggested that EOC patients with down-regulated miR-1 expression and up-regulated miR-23 expression have shorter overall survival when compared with patients with other expression groups (log-rank test P<.1). Multivariate Cox proportional hazards model indicated that the status of miR-1 and miR-23 expression levels were independent predictor of overall survival in patients with EOC. Conclusion: Decreased expression and increased expression of miR-1 and miR-23 may be correlated with progression and poor prognosis of EOC.

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