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A Single-Flask Synthesis of Morita-Baylis-Hillman Adducts from Ethoxyacetylene and Carbonyl Compounds: Synthesis of Subamolides D and E

Lithiation of ethoxyacetylene and sequential addition reaction with aldehydes and/or ketones and BF3·OEt2 leads to 2-hydroxymethyl enoates in good to excellent overall yields.

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