Thesis

The multicomponent nature of teratoma cell adhesion factor

The complex nature of the teratoma cell adhesion system has been demonstrated. Fractionation of crude ascites fluid on a DEAE cellulose ion exchange column made it possible to show that two or more components are involved in teratoma adhesion factor (TAF) activity. Glycoproteins in fractionated ascites fluid were localized on polyacrylamide gels. The possible role of these glycoproteins in teratoma cell adhesion and current hypotheses on the mechanism of carbohydrate involvement in intercellular adhesion are discussed.

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