Chemotherapy Related Cognitive Impairment

Little is known about cognitive impairment related to chemotherapy. Patients who receive chemotherapeutic drugs report cognitive impairment during or subsequent to treatment (Raffa, 2010). It is vital to determine the short-term and long-term consequences of cognitive change related to chemotherapy and its impact on quality of life. A great need exists for research focused on the effects of high dose chemotherapy on cognitive function. In addition, large-scale prospective clinical trials with longitudinal design and appropriate controls to evaluate the probability of chemotherapy related cognitive impairment are needed. Currently, there are no reported studies that have investigated the effects of high dose Melphalan on cognitive function for individuals with multiple myeloma in the setting of a stem cell transplant.