Masters Thesis

Identification of cutaneous bacterial species with anti-dermatophyte properties from Rana catesbeiana, the North American bullfrog

There is a possibility to eradicate infectious diseases with antibiotics. However, new infectious diseases are continually being identified and some known pathogens are again becoming a threat because of antibiotic resistance. Amphibians mostly live in a moist environment which is the best condition for the growth of bacteria and fungi as well. Antimicrobial peptides produced by serous glands in the amphibian skin play a key role in limiting microbial growth and preventing infections with pathogenic microorganisms. In addition to the antimicrobial peptides produced by serous glands, microbial symbionts on the bullfrog skin are also a source of antimicrobial peptides that can protect the amphibian against diseases. In this research, we investigated whether cutaneous bacterial species isolated from Rana catesbeiana (North American Bullfrog), an amphibian species that is resistant to chytridiomycosis, produce secondary metabolites that could be used to inhibit the growth of three species of dermatophytes (Microsporum gypseum, Epidermotphyton floccosum, Trichophyton mentagrophytes) which are known to cause skin infections in humans. The isolated bacterial species from R. catesbeiana may be useful as producers of antifungal metabolites that kill, or inhibit the growth of, dermatophytes known to cause topical or subdermal skin infections in humans.

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