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Neutralization of Bacillus pumilus lactate dehydrogenase by homologous antibody.
The discovery of antitoxins to both diphtheria and tetanus toxins dramatically introduced two immunological phenomena to twentieth-century science. First, biologically active molecules, such as toxins and enzymes, may have the potential to be neutralized by antibody; secondly, this gave the first proof of the existence of specific antibodies. These findings sparked a determination to reveal the actual mechanism of combination of antigens and antibodies, and introduced some of the concepts and techniques of physics and chemistry into the field of immunology.