The influence of culture media upon the disposition of certain bacteria to the phagocytic action of guinea pig leucocytes
The variability of the phagocytic action has been known for nearly half a century. first being shown clearly by Shattock and Dudgeon (1908). Experiments by Dixon and McCutcheon (1938) were designed to show whether bacteria chemotropically attract leucocytes directly. or only indirectly as the result of injuring cells and tissues, and causing these to liberate chemotropic substances. The results showed that leucocytes may react chemotropic ally to substances given off directly by bacteria. As the leucocytes would migrate across a zone of cell-free plasma towards the bacteria, there was a definite indication that leucocytes react chemotropic ally to substances given off directly by bacteria and not to substances from injured tissue cells.