Sarcoma 180 adhesion factor

Ascites fluid from mice 'bearing the Sarcoma 180 ascites tumor enhances the rotation mediated aggregation of S-180 ascites tumor cells, Evidence presented suggests that the aggregation promoting component of the ascites fluid is not produced by the host, and is therefore probably an extracellular product of the ascites tumor cells. This aggregation promoting substance increases the rate of aggregation of two other ascites tumor lines and the reaggregation of chick neural retina. The effect of S-180 ascites fluid on these heterologous cell types, however, is usually less than that on S-180 cells. (See more in text.)