Thesis

The display of lectin receptor sites on the surfaces of tumor and embryonic cell populations

This study: a) describes a method employing microfluorometry to measure the fluorescence intensity of cell surface areas labeled with a fluorescent lectin (fluorescein isothiocyanate-conjugated concanavalin A), b) determines some parameters of binding and distribution of fluorescent lectins to cell surfaces, c) shows that concanavalin A receptor sites appear to be more mobile on specific migratory embryonic cell populations (sea urchin embryonic micromeres) as indicated by clustering of the fluorescent labeled lectin on the cell surface, d) indicates that cytochalasin B, a microfilament disrupting drug, affects not only the gross conformation of the plasma membrane but also the distribution of surface concanavalin A receptor sites of mouse Sarcoma 180 ascites tumor cells.

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