Masters Thesis

Induction and physiological-genetic characterizations of selected Staphylococcus aureau strains.

The L-Form of Staphylocoecus aureus is of interest from a clinical point of view since it has been often associated with certain diseases. S- aureus L-Forms have been isolated from recurrent osteomyelitis (Rosner, 1968)., In addition, Kagan (1972) reported isolation of L-Forms of S aureus from recurrent furunculosis, from blood cultures of a leukemia patient, and from sputum of some patients with cystic fibrosis. Because L-Forms are cell wall deficient organisms, they may survive in vivo, under conditions that would not allow survival of intact bacteria. The lack of cell wall or presence of cell wall remnants in these variants has been established by chemical analysis. Pratt (1966) found that L-Forms of S_. aureus contain negligible amounts of muramic acid and no teichoic acids. Chatterjee et al. (1967) reported the presence of only mucopeptide intermediates and only some of the enzymes responsible for cell wall synthesis in this organism.