Relationship between intercellular adhesiveness and glutamine synthetase specific activity in synchronized cultures of mouse teratoma cells

In cultures of mouse teratoma, cells synchronized with thymidine (3mM) and colcemid (0.5 mcg/ml), cellular adhesiveness displayed an oscillatory pattern with peaks of glutamine synthtase (GS} specific activity occurring lust prior to peaks of adhesiveness. The results demonstrate a correlation between GS specific activity and cellular adhesiveness. Based upon previous work which implies L.-glutamine in intercellular adhesion, it is not unreasonable to speculate that GS specific activity and cellular adhesiveness may be causally related.