Hydrocortisone induced stimulation of teratoma cell adhesiveness

Specific levels of active glutamine synthetase (GS) may be involved in regulating intercellular adhesiveness in teratoma, as well as other cell types. To investigate this question, two teratoma cell lines were incubated with hydrocortisone (HC), a hormone known to stimulate cellular GS specific activity levels. Under conditions of HC incubation, increased GS specific activity and intercellular adhesion were observed. The increased adhesiveness may be directly related to the increased GS specific activity through the synthesis of L-glutamine which is required for intercellular adhesion.